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Although these agents are effective, they present several significant limitations: Safety concerns Biologics : Agents such as tumour necrosis factor- (TNF-) antagonists (e.g., infliximab, adalimumab, and etanercept) have revolutionised the treatment of rheumatoid arthritis and inflammatory bowel disease

Later, similar observations were made in gastrointestinal tumors, neuroblastomas, renal tumors, thyroid tumors, and testicular tumors 125,126

Enhanced angiogenesis counters the reduced vascularization typical in diabetic tissue

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Seven doses a week